| Identification | Back Directory | [Name]
lactoquinomycin B | [CAS]
101342-94-3 | [Synonyms]
lactoquinomycin B
3a,11b-Dihydro-7-hydroxy-5-methyl-8-[2,3,6-trideoxy-3-(dimethylamino)-β-D-arabino-hexopyranosyl]-5a,11a-epoxy-5H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11(3H)-trione
5a,11a-Epoxy-5H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11(3H)-trione, 3a,11b-dihydro-7-hydroxy-5-methyl-8-[2,3,6-trideoxy-3-(dimethylamino)-β-D-arabino-hexopyranosyl]- | [Molecular Formula]
C24H27NO9 | [MOL File]
101342-94-3.mol | [Molecular Weight]
473.47 |
| Chemical Properties | Back Directory | [Melting point ]
149-152 °C (decomp) | [Boiling point ]
736.8±60.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [pka]
6.15±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Lactoquinomycin B is a quinone antibiotic. Lactoquinomycin B has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin B inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.43, 0.21, 0.19, 0.16, 0.2 and 0.12, respectively[1]. | [References]
[1] T Okabe, et al. Lactoquinomycin B, a novel antibiotic. J Antibiot (Tokyo). 1986 Jan;39(1):1-5. |
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