| Identification | Back Directory | [Name]
curvularin | [CAS]
10140-70-2 | [Synonyms]
curvularin
(S)-Curvularin
S-Curvularin, NSC 166071
2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)- | [Molecular Formula]
C16H20O5 | [MDL Number]
MFCD09752718 | [MOL File]
10140-70-2.mol | [Molecular Weight]
292.33 |
| Chemical Properties | Back Directory | [Melting point ]
206-206.5° | [alpha ]
D18 -36.3° (c = 3.8 in ethanol) | [Boiling point ]
557.0±29.0 °C(Predicted) | [density ]
1.200±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble1mg/mL | [form ]
powder | [pka]
7.58±0.40(Predicted) | [color ]
Off-white |
| Hazard Information | Back Directory | [Uses]
Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species, including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology. | [storage]
Store at -20°C |
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