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101784-44-5

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101784-44-5 Structure

101784-44-5 Structure
IdentificationBack Directory
[Name]

CAY10704
[CAS]

101784-44-5
[Synonyms]

CAY10704
CAY10704,CAY-10704
Piperazine, 1-[bis(4-chlorophenyl)methyl]-4-methyl-
[Molecular Formula]

C18H20Cl2N2
[MOL File]

101784-44-5.mol
[Molecular Weight]

335.27
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 20 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 20 mg/ml; Ethanol: 16 mg/ml
Safety DataBack Directory
[Symbol(GHS) ]


GHS02
[Signal word ]

Danger
Hazard InformationBack Directory
[Description]

CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 μM).1 It displays good pharmacokinetics in mice when delivered intraperitoneally, with preferential liver distribution without significant hepatotoxicity.1 CAY10704 is selective for HCV over dengue virus (EC50 = 4.62 μM).1
[References]

1. He, S., Xiao, J., Dulcey, A.E., et al. Discovery, optimization, and characterization of novel chlorcyclizine derivatives for the treatment of hepatitis C virus infection J. Med. Chem. 59(3),841-853(2016).
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