| Identification | Back Directory | [Name]
13(R)-HODE | [CAS]
10219-69-9 | [Synonyms]
13(R)-HODE
Coriolic acid
13(R) HODE,13(R)HODE
HNICUWMFWZBIFP-PIHGWCCBSA-N
13(R)-hydroxy-9,11-octadienoic acid
13R-HYDROXY-9Z,11E-OCTADECADIENOIC ACID
(R-(E,Z))-13-Hydroxy-9,11-octadecadienoic acid
(R,9Z,11E)-13-Hydroxy-9,11-octadecadienoic acid
9,11-Octadecadienoic acid, 13-hydroxy-, (R-(E,Z))-
9,11-Octadecadienoic acid, 13-hydroxy-, (9Z,11E,13R)- | [Molecular Formula]
C18H32O3 | [MDL Number]
MFCD00084834 | [MOL File]
10219-69-9.mol | [Molecular Weight]
296.44 |
| Hazard Information | Back Directory | [Description]
13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase. The presence of 13(R)-HODE in the supernatants and membranes of cultured bovine endothelial cells has been attributed to COX metabolism.1 13(R)-HODE is a weak (IC50 = 2.7 μM) inhibitor of U-46619-induced platelet aggregation.2 | [Definition]
ChEBI: 13(R)-HODE is a 13-HODE in which the stereocentre at position 13 has S-configuration. It is a conjugate acid of a 13(R)-HODE(1-). | [References]
1. Baer, A.N., Costello, P.B., and Green, F.A. Stereospecificity of the hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids produced by cultured bovine endothelial cells Biochim. Biophys. Acta 1085(1),45-52(1991).
2. Lagarde, M., Boutillon, M.M., Guichardant, M., et al. Further studies on the anti-thromboxane A2 activity of monohydroxylated fatty acids Biochem. Pharmacol. 38,1863-1864(1989). |
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