| Identification | Back Directory | [Name]
VX-222 | [CAS]
1026785-59-0 | [Synonyms]
VCH222
VX-222
CS-481
VCH 222
VCH-222
VX-222, VCH222
VX222(Lomibuvir)
Lomibuvir (VX-222
VX-222 (VCH-222, LoMibuvir)
Lomibuvir (VX-222, VCH-222)
VCH222; VX 222; VCH 222; VCH-222;VX-222
5-(3,3-Dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid
2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]- | [Molecular Formula]
C25H35NO4S | [MDL Number]
MFCD18089858 | [MOL File]
1026785-59-0.mol | [Molecular Weight]
445.61 |
| Chemical Properties | Back Directory | [Boiling point ]
640.5±55.0 °C(Predicted) | [density ]
1.21 | [storage temp. ]
Store at -20°C | [solubility ]
≥44.6 mg/mL in DMSO; insoluble in H2O; ≥97.2 mg/mL in EtOH | [form ]
solid | [pka]
3.67±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Lomibuvir is a non-nucleoside inhibitor of the RNA-directed RNA polymerase of hepatitis C virus (HCV; Ki = 17 nM) that inhibits primer-dependent RNA synthesis selectively over de novo RNA synthesis. It inhibits HCV replication in Huh7.5 cells expressing the 1b/Con1 HCV subgenomic replicon (EC50 = 5 nM). | [Uses]
VX-222, s a novel, potent and selective inhibitor of HCV polymerase . | [Definition]
ChEBI: 5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-[(4-methylcyclohexyl)-oxomethyl]amino]-2-thiophenecarboxylic acid is a thiophenecarboxylic acid. | [target]
HCV RNA-dependent RNA polymerase |
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