| Identification | Back Directory | [Name]
L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(2-fluoroacetyl)-4-methoxy-4-oxobutyl]- | [CAS]
1027141-02-1 | [Synonyms]
L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(2-fluoroacetyl)-4-methoxy-4-oxobutyl]- | [Molecular Formula]
C23H32FN3O7 | [MOL File]
1027141-02-1.mol | [Molecular Weight]
481.51 |
| Hazard Information | Back Directory | [Description]
Z-VAE(OMe)-fmk is a cell-permeable and irreversible UCHL1 inhibitor. The inhibitor approaches the active-site cleft from the opposite side of the crossover loop as compared to the direction of approach of ubiquitin's C-terminal tail, thereby occupying the P1' (leaving group) site, a binding site perhaps used by the unknown C-terminal extension of ubiquitin in the actual in vivo substrate(s) of UCHL1. |
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