| Identification | Back Directory | [Name]
H-ALA-LYS-PHE-ASP-LYS-PHE-TYR-GLY-LEU-MET-NH2 | [CAS]
103425-21-4 | [Synonyms]
SCY 1
AKFDKFYGLM
SCYLIORHININ I
Scyliorhinin I, Scy I
SCYLIORHININ I AMIDE (DOGFISH)
SHARK SUBSTANCE P RELATED PEPTIDE
Scy I: Shark Substance P Related Peptide
ALA-LYS-PHE-ASP-LYS-PHE-TYR-GLY-LEU-MET-NH2
H-ALA-LYS-PHE-ASP-LYS-PHE-TYR-GLY-LEU-MET-OH
H-ALA-LYS-PHE-ASP-LYS-PHE-TYR-GLY-LEU-MET-NH2
L-Ala-L-Lys-L-Phe-L-Asp-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2
Physalemin, 1-de(5-oxo-L-proline)-3-L-lysine-4-L-phenylalanine-5-L-aspartic acid-
L-Methioninamide, L-alanyl-L-lysyl-L-phenylalanyl-L-α-aspartyl-L-lysyl-L-phenylalanyl-L-tyrosylglycyl-L-leucyl- | [Molecular Formula]
C59H87N13O13S | [MDL Number]
MFCD00080017 | [MOL File]
103425-21-4.mol | [Molecular Weight]
1218.47 |
| Hazard Information | Back Directory | [Uses]
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a Ki value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum[1][2]. | [IC 50]
rat NK1: 0.9 nM (Ki); guinea pig NK-2: 2 nM (Ki) | [References]
[1] Conlon, et al. "Scyliorhinin I and II: two novel tachykinins from dogfish gut." FEBS letters 200.1 (1986): 111-116. DOI:10.1016/0014-5793(86)80521-x
[2] Stephen H, et al. "The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors." European journal of pharmacology 144.1 (1987): 109-111. DOI:10.1016/0014-2999(87)90017-3 |
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