| Identification | Back Directory | [Name]
trace amine receptor 1 | [CAS]
1043495-96-0 | [Synonyms]
tar1
rTAR1
TAAR1
TRAR1
snorf33
RO-5256390
RP11-295F4.9
RO-5256390,RO5256390
trace amine receptor 1
trace amine associated receptor 1
Anti-TAAR1 antibody produced in rabbit
Anti-TAAR1/TA1 antibody produced in rabbit
2-Oxazolamine, 4,5-dihydro-4-[(2S)-2-phenylbutyl]-, (4S)-
(4S)-4-((2S)-2-phenylbutyl)-4,5-dihydro-1,3-oxazol-2-ylamine | [Molecular Formula]
C13H18N2O | [MDL Number]
MFCD28405494 | [MOL File]
1043495-96-0.mol | [Molecular Weight]
218.29 |
| Chemical Properties | Back Directory | [Boiling point ]
330.9±25.0 °C(Predicted) | [density ]
1.13±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8.58±0.70(Predicted) | [color ]
White to off-white | [biological source]
rabbit | [optical activity]
[α]/D 14 to 19°, c =1 in methanol |
| Hazard Information | Back Directory | [Uses]
RO 5256390 is a trace amine-associated receptor 1(TAAR1) agonist which may be used as treatment of cocaine addiction. | [Biological Activity]
RO5256390 is an agonist of Trace amine-associated receptor 1 (TAAR1)a GPCR primarily found in the brainexpressed in areas where the major monoamine amine transmitters (DA and NE) are also present. RO5256390 is a selective TAAR1 agonist shown to be a negative regulator of dopamine transmission. It has antipsychotic activity in models of schizophreniareduces cocaineμs reinforcng effectsand blocks binge-eating disorder. |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
|