| Identification | Back Directory | [Name]
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid | [CAS]
104561-41-3 | [Synonyms]
EC 23
BASF-46928
OQVLOWLEEHYBJH-UHFFFAOYSA-N
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid
Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]- | [Molecular Formula]
C23H24O2 | [MDL Number]
MFCD18086921 | [MOL File]
104561-41-3.mol | [Molecular Weight]
332.44 |
| Chemical Properties | Back Directory | [Melting point ]
254-256 °C(Solv: acetonitrile (75-05-8)) | [Boiling point ]
484.7±45.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml | [form ]
White to off-white lyophilised amorphous solid. | [pka]
4.10±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
EC 23 is an ATRA analog with similar activity. EC 23 potently induces neural differentiation in human pluripotent embryonic stem cells. | [Biological Activity]
EC23 is a syntheticphotostable all-trans retinoic acid (ATRA) analog/mimetic th at targets RAR with greater affinity than ATRA (RARα/β/γ EC50 by cell-free TR-FRET binding assay = 3.7/3.3/16.8 with EC23 vs. 16.0/17.6/14.7 nM with ATRA) and does not bind retinoid x receptors (RXRs). EC23 induces differentiation of human pluripotent embryonic stem cells (0.1-10 μM) with a similar or better efficiency than ATRA. | [storage]
+4°C |
|
| Company Name: |
|
| Tel: |
821-50328103-801 18930552037 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm |
|