| Identification | Back Directory | [Name]
Cereblon Ligand 1 | [CAS]
1061605-21-7 | [Synonyms]
TC E3 5031
Thalidomide-Acid
Cereblon ligand 3
Cereblon Ligand 1
Thalidomide-O-COOH
Thalidomide-4-hydroxyacetate
Pomalidomide Related Compound 1
2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetic acid
2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid
2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid
Acetic acid, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- | [Molecular Formula]
C15H12N2O7 | [MDL Number]
MFCD31560477 | [MOL File]
1061605-21-7.mol | [Molecular Weight]
332.27 |
| Chemical Properties | Back Directory | [Boiling point ]
660.5±55.0 °C(Predicted) | [density ]
1.606±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DCM | [form ]
A crystalline solid | [pka]
2.95±0.10(Predicted) | [InChI]
InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21) | [InChIKey]
ZVWIXIGBWIEDFO-UHFFFAOYSA-N | [SMILES]
C(O)(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O |
| Hazard Information | Back Directory | [Description]
Thalidomide-Acid is a linker of Thalidomide which is commonly used as a precursor to PROTAC that hijacks cereblon as the E3 ubiquitin ligase component. | [Uses]
Thalidomide-4-hydroxyacetate is a proteolysis targeting chimeras which allows for the optical control of protein degradation. | [Solubility in organics]
DMF: 30 mg/ml
DMSO: 30 mg/ml
PBS (pH 7.2): 1 mg/ml | [storage]
Store at RT |
|
|