| Identification | Back Directory | [Name]
1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester | [CAS]
1087243-14-8 | [Synonyms]
GRL-0496
1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester
chloropyridyl,GRL-0496,3CLpro,inhibit,GRL0496,Inhibitor,SARS-CoV,GRL 0496,SARS coronavirus | [Molecular Formula]
C14H9ClN2O2 | [MDL Number]
MFCD34471049 | [MOL File]
1087243-14-8.mol | [Molecular Weight]
272.69 |
| Chemical Properties | Back Directory | [storage temp. ]
-20° | [solubility ]
Soluble in DMSO (>30 mg/mL) and ethanol (>25 mg/mL) | [form ]
solid | [color ]
White | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
GRL-0496 (1087243-14-8) is a potent (IC50?= 30 nM in cell culture assays) inhibitor of severe acute respiratory syndrome-coronavirus chymotrypsin-like protease (SARS-CoV 3CLpro).1 | [Definition]
ChEBI: (5-Chloropyridin-3-yl) 1H-indole-4-carboxylate is an indolyl carboxylic acid. It has a role as an anticoronaviral agent. | [storage]
Store at -20°C | [References]
1)????Ghosh?et al. (2008),?Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors;?Bioorg. Med. Chem.Lett,?18?5684 |
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