| Identification | Back Directory | [Name]
EzetiMibe-d4 | [CAS]
1093659-89-2 | [Synonyms]
[2H4]-Ezetimibe
Ezetimibe Impurity 119
(3R,4S)-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-3-[(3S)-3-hydroxy-3-(2,3,5,6-tetradeuterio-4-fluorophenyl)propyl]azetidin-2-one
Ezetimibe D4Q: What is
Ezetimibe D4 Q: What is the CAS Number of
Ezetimibe D4 Q: What is the storage condition of
Ezetimibe D4 | [Molecular Formula]
C24H21F2NO3 | [MOL File]
1093659-89-2.mol | [Molecular Weight]
409.43 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Ezetimibe-d4 is intended for use as an internal standard for the quantification of ezetimibe by GC- or LC-MS. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Upon oral administration ezetimibe undergoes rapid glucuronidation in the intestine where its glucuronide binds NPC1L1. Ezetimibe exhibits ED50 values of 0.0005-0.05 mg/kg in various animal models, selectively blocking cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen, affecting bile acid micelle solubilization of cholesterol, or interfering with the absorption of triglycerides, fatty acids, or bile acids. | [Uses]
Ezetimibe-d4 is the labeled analogue of Ezetimibe (E975000), an antihyperlipoproteinemic. A cholesterol absorption inhibitor. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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