| Identification | Back Directory | [Name]
N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide | [CAS]
1109283-93-3 | [Synonyms]
MARK-IN-1
MARK IN 1,MARKIN1
N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a
N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide
N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide
2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]- | [Molecular Formula]
C22H23F2N7OS | [MDL Number]
MFCD22419376 | [MOL File]
1109283-93-3.mol | [Molecular Weight]
471.53 |
| Hazard Information | Back Directory | [Description]
MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of <0.25 nM. MARK-IN-1 (Compound 25) is a potent MARK inhibitor. Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease[1]. | [storage]
Store at -20°C | [References]
[1]. Sloman DL, et al. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4362-6. |
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Matrix Scientific
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803 788-9494 All other calls |
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www.matrixscientific.com |
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