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111686-79-4

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111686-79-4 Structure

111686-79-4 Structure
IdentificationBack Directory
[Name]

2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
[CAS]

111686-79-4
[Synonyms]

fpl12924aa
pr934-423a
RemacemideHCl
REMACEMIDE HYDROCHLORIDE
2-AMino-N-(1,2-diphenylpropan-2-yl)acetaMide hydrochloride
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
2-diphenylethyl)acetamidemonohydrochloride(+-)-2-amino-n-(1-methyl-
2-amino-n-(1-methyl-1,2-diphenylethyl)-,monohydrochloride,(+-)-acetamid
[Molecular Formula]

C17H21ClN2O
[MDL Number]

MFCD00882179
[MOL File]

111686-79-4.mol
[Molecular Weight]

304.81
Chemical PropertiesBack Directory
[Melting point ]

253-254°
[storage temp. ]

room temp
[solubility ]

H2O: >10mg/mL
[form ]

powder
[color ]

white to beige
[Water Solubility ]

Soluble to 100 mM in water
Safety DataBack Directory
[Hazard Codes ]

Xn,N
[Risk Statements ]

22-41-50/53
[Safety Statements ]

26-39-45-60-61
[RIDADR ]

UN 3077 9 / PGIII
[WGK Germany ]

3
[RTECS ]

AB4349500
[Toxicity]

LD50 (calculated as base) in rats (mg/kg): ~50 i.v., ~900 orally (Muir, Palmer)
Hazard InformationBack Directory
[Uses]

Anticonvulsant (neuroprotective).
[Biological Activity]

Non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC 50 = 8-68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na + channels (IC 50 = 161 mM).
[Biochem/physiol Actions]

Remacemide HCl is a low affinity NMDA antagonist with anticonvulsant properties. Remacemide also been shown to block voltage-dependent sodium channels.
[storage]

Desiccate at RT
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