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1119503-63-7

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1119503-63-7 Structure

1119503-63-7 Structure
IdentificationBack Directory
[Name]

N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide
[CAS]

1119503-63-7
[Synonyms]

JNc-440 (JNc440)
N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide
[Molecular Formula]

C26H24N4O3
[MOL File]

1119503-63-7.mol
[Molecular Weight]

440.49
Chemical PropertiesBack Directory
[density ]

1.26±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

10.06±0.20(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice[1]. JNc-440 (1 mg/kg; IV; single dosage) improves endothelium-dependent relaxation in small resistance arteries and to lower blood pressure[1].
[storage]

Store at -20°C
[References]

[1]. He D, et al. Treatment of hypertension by increasing impaired endothelial TRPV4-KCa2.3 interaction. EMBO Mol Med. 2017 Nov;9(11):1491-1503.
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