| Identification | Back Directory | [Name]
CAPECITABINE-D11 | [CAS]
1132662-08-8 | [Synonyms]
Xeloda-d11
Captabin-d11
Capiibine-d11
Ro 09-1978-d11
CAPECITABINE-D11
Capecitibine-d11
Capecytabine-d11
Ro 09-1978/000-d11
5'-DEOXY-5-FLUORO-N-[(PENTYLOXY)CARBONYL]CYTIDINE-D11
5'-Deoxy-5-fluoro-N-[(pentyl-d11-oxy)carbonyl]cytidine
[1-(5-Deoxy-α-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyriMidinyl]carbaMic Acid Pentyl-11 Ester | [Molecular Formula]
C15H13D11FN3O6 | [MDL Number]
MFCD07369214 | [MOL File]
1132662-08-8.mol | [Molecular Weight]
372.43 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Powder | [Melting point ]
45-50°C | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [color ]
Off-White to Pale Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Powder | [Uses]
An isotopically labelled antineoplastic agent. A prodrug of Doxifluridine (D556750). | [Uses]
An isotopically labelled antineoplastic agent. A prodrug of Doxifluridine.;Labeled Capecitabine, intended for use as an internal standard for the quantification of Capecitabine by GC- or LC-mass spectrometry. | [Description]
Capecitabine-d11 is intended for use as an internal standard for the quantification of capecitabine by GC- or LC-MS. Capecitabine is a prodrug form of 5-fluorouracil (5-FU). It is converted to 5-FU via several enzymatic steps beginning in the liver and ending with conversion in tumor tissue by thymidine phosphorylase, an enzyme that is more concentrated in tumor tissue compared with normal tissue. Capecitabine is cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 μM, respectively) and is inactive in a variety of cancer cell lines, including COLO 205, HCT116, and MCF-7 cells (IC50s = >1,000 μM). |
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