| Identification | Back Directory | [Name]
[2H7]-Alfuzosin | [CAS]
1133386-93-2 | [Synonyms]
[2H7]-Alfuzosin
Alfuzosin D7Q: What is
Alfuzosin D7 Q: What is the CAS Number of
Alfuzosin D7 Q: What is the storage condition of
Alfuzosin D7 Q: What are the applications of
Alfuzosin D7 | [Molecular Formula]
C19H27N5O4 | [MOL File]
1133386-93-2.mol | [Molecular Weight]
389.46 |
| Hazard Information | Back Directory | [Biological Activity]
Alfuzosin-d7 is intended for use as an internal standard for the quantification of alfuzosin by GC- or LC-MS. Alfuzosin is an antagonist of α1-adrenergic receptors (α1-ARs; Kis = 10, 10, and 3.16 nM for α1A-, α1B-, and α1D-ARs, respectively).1 It increases the amount of phenylephrine needed to increase urethral and arterial blood pressure in pithed rats when administered at a dose of 10 mg/kg.2 Formulations containing alfuzosin have been used in the treatment of benign prostatic hyperplasia. | [References]
1.Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al.Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studiesBr. J. Pharmacol.118(4)871-878(1996)
2.Martin, D.J., Lluel, P., Pouyet, T., et al.Relationship between the effects of alfuzosin on rat urethral and blood pressures and its tissue concentrationsLife Sci.63(3)169-176(1998)
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