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1135278-41-9

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1135278-41-9 Structure

1135278-41-9 Structure
IdentificationBack Directory
[Name]

SR 59230A HCl
[CAS]

1135278-41-9
[Synonyms]

SR-59230A hydrochloride,SR59230A hydrochloride
[Molecular Formula]

C21H27NO2.HCl
[MDL Number]

MFCD06795851
[MOL File]

1135278-41-9.mol
[Molecular Weight]

361.91
Chemical PropertiesBack Directory
[storage temp. ]

Store at 4°C
[solubility ]

Soluble in DMSO
[form ]

solid
[color ]

White
Hazard InformationBack Directory
[Description]

SR 59230A (hydrochloride) is a β3-adrenergic receptor (β3-AR) antagonist (pA2s = 8.76, 7.31, and 6.63 in rat proximal colon, guinea pig atrium, and guinea pig trachea, respectively). It is less selective for β3-AR in cells transfected with the human β-AR subtypes (Kis = 16.4, 61.9, and 122 nM for β1-, β2-, and β3-AR, respectively). At low concentrations, SR 59230A blocks MDMA-induced hyperthermia, while at high concentrations it blocks hyperthermia but also increases heat loss through an α1-AR antagonistic mechanism. In adipocytes, it induces phosphorylation of p38 MAPK via the Gs pathway. It has also been used in studies of heart failure to elucidate the role of the β3-ARs.
[Uses]

SR 59230A Hydrochloride is a potent and selective β3 adrenergic receptor antagonist.
[storage]

Store at 4°C
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