| Identification | Back Directory | [Name]
PHACLOFEN | [CAS]
114012-12-3 | [Synonyms]
PHACLOFEN
PHACLOFEN GABA(B) RECEPTOR ANTA
3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID
3-amino-2-(4-chlorophenyl)*propanephosphonic acid
(RS)-3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID
Phosphonic acid, (3-amino-2-(4-chlorophenyl)propyl)-
Phosphonic acid, P-[3-amino-2-(4-chlorophenyl)propyl]-
Phaclofen,(RS)-3-Amino-2-(4-chlorophenyl)propylphosphonicaci | [Molecular Formula]
C9H13ClNO3P | [MDL Number]
MFCD00069328 | [MOL File]
114012-12-3.mol | [Molecular Weight]
249.63 |
| Hazard Information | Back Directory | [Uses]
Phaclofen is a selective GABAB?receptor antagonist. | [General Description]
Phaclofen is a phosphonic acid derivative of baclofen. | [Biological Activity]
Selective GABA B antagonist. Phosphono analog of GABA B agonist baclofen ((RS)-4-Amino-3-(4-chlorophenyl)butanoic acid ). | [Biochem/physiol Actions]
Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (?) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons. |
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