| Identification | Back Directory | [Name]
E-7449 | [CAS]
1140964-99-3 | [Synonyms]
E7449
E-7449
E7449;E 7449
8-(1,3-dihydro-isoindol-2-ylmethyl)-2,9-dihydro-1,2,7,9-tetraaza-phenalen-3-one
3H-Pyridazino[3,4,5-de]quinazolin-3-one, 8-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-1,2-dihydro- | [Molecular Formula]
C18H15N5O | [MDL Number]
MFCD28167842 | [MOL File]
1140964-99-3.mol | [Molecular Weight]
317.34 |
| Chemical Properties | Back Directory | [density ]
1.53±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:0.2(Max Conc. mg/mL);0.63(Max Conc. mM) | [form ]
A crystalline solid | [pka]
9.51±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
E 7449 is a dual inhibitor of PARP1/2 and tankyrase1/2 exhibits anti-tumor activity in BRCA-deficient in vivo models. PARP1/2 and tankyrase1/2 are involved with DNA damage and canonical Wnt/β-catenin signaling, respectively. |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|