| Identification | Back Directory | [Name]
1--D-Glucosylsphingadienine (d18:2 (4E,8E)) | [CAS]
114200-59-8 | [Synonyms]
1--D-Glucosylsphingadienine (d18:2 (4E,8E))
1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))
β-D-Glucopyranoside, (2S,3R,4E,8E)-2-amino-3-hydroxy-4,8-octadecadienyl (9CI) | [Molecular Formula]
C24H45NO7 | [MOL File]
114200-59-8.mol | [Molecular Weight]
459.62 |
| Hazard Information | Back Directory | [Description]
1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides (Item Nos. 23206 | 23207). They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher''s disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3); thus, glucosylsphingosine has been used as a key biomarker of the disease. This product contains 1-β-D-glucosylsphingadienine isolated from plants. [Matreya, LLC. Catalog No. 1310] |
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