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1143020-91-0

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1143020-91-0 Structure

1143020-91-0 Structure
IdentificationBack Directory
[Name]

AZ-GHS-22
[CAS]

1143020-91-0
[Synonyms]

AZ-GHS-22
[Molecular Formula]

C27H33ClN6O5S2
[MOL File]

1143020-91-0.mol
[Molecular Weight]

621.17
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[solubility ]

0.1 M HCl: 25 mg/ml,DMSO: 50 mg/ml
[form ]

A solid
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302+H312+H332-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
Hazard InformationBack Directory
[Biological Activity]

AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.1 It binds to GHS-R1a with an IC50 value of 0.77 nM. AZ-GHS-22 decreases food intake in mice by 54% in the first two hours after administration of a 100 mg/kg dose.
[storage]

-20°C
[References]

1.McCoull, W., Barton, P., Brown, A.J.H., et al.Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonistsJ. Med. Chem.57(14)6128-6140(2014)
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