| Identification | Back Directory | [Name]
3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid | [CAS]
1143579-78-5 | [Synonyms]
II-B08
3-(1-(3-([1
FAP1 Inhibitor
LMWPTP Inhibitor
CD45 Inhibitor V
Lyp Inhibitor III
1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1
3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid | [Molecular Formula]
C33H27N5O4 | [MDL Number]
MFCD32645102 | [MOL File]
1143579-78-5.mol | [Molecular Weight]
557.599 |
| Hazard Information | Back Directory | [Description]
II-B08, also known as PTP Inhibitor XXXI, is a cell-permeable SHP2 inhibitor (IC50 = 5.5 μM). II-B08 blocks growth factor stimulated ERK1/2 activation and hematopoietic progenitor proliferation, providing supporting evidence that chemical inhibition of SHP2 may be therapeutically useful for anticancer and antileukemia treatment. X-ray crystallographic analysis of the structure of SHP2 in complex with 9 reveals molecular determinants that can be exploited for the acquisition of more potent and selective SHP2 inhibitors. |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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