| Identification | Back Directory | [Name]
Benzeneacetamide, 3,4-dichloro-N-methyl-N-[1,2,3,4-tetrahydro-5-methoxy-2-(1-pyrrolidinyl)-1-naphthalenyl]-, monohydrochloride, trans- | [CAS]
115904-74-0 | [Synonyms]
DuP 747 HCl
Benzeneacetamide, 3,4-dichloro-N-methyl-N-[1,2,3,4-tetrahydro-5-methoxy-2-(1-pyrrolidinyl)-1-naphthalenyl]-, monohydrochloride, trans- | [Molecular Formula]
C24H28Cl2N2O2.ClH | [MOL File]
115904-74-0.mol | [Molecular Weight]
483.86 |
| Hazard Information | Back Directory | [Uses]
DuP 747 hydrochloride is an analgesic with selective kappa-opioid receptor agonist activity. DuP 747 showed less spiradoline-appropriate selection when administered SC, but showed a partial generalized response to spiradoline when administered IP or PO. The 5-hydroxy-desmethoxy metabolite of DuP 747 induced selection of the saline-appropriate lever only. The effects of DuP 747 suggest that its metabolites may play a major role in the similar responses to spiradoline after IP and PO administration[1]. | [References]
[1] Assessing spiradoline-like discriminative effects of DuP 747: influence of route of administration DOI:10.1016/0091-3057(94)90148-1 |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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www.biorbyt.com |
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