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116380-66-6

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116380-66-6 Structure

116380-66-6 Structure
IdentificationBack Directory
[Name]

CHOLIC-2,2,4,4-D4 ACID
[CAS]

116380-66-6
[Synonyms]

Cholic-d4 Acid
Cholic acid-2,2,4,4-d
Cholic Acid -[d4] (Solution)
Cholic Acid-d4 MaxSpec? Standard
5β-cholanic acid-3α,7α,12α-triol-2,2,4,4-d4
CHOLIC ACID (2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL
[Molecular Formula]

C24H36D4O5
[MDL Number]

MFCD00190405
[MOL File]

116380-66-6.mol
[Molecular Weight]

412.6
Chemical PropertiesBack Directory
[Melting point ]

200-201°C (lit.)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
[form ]

Solid
[color ]

White to Off-White
Safety DataBack Directory
[Symbol(GHS) ]


GHS02,GHS08
[Signal word ]

Danger
[Hazard statements ]

H225-H370
[Precautionary statements ]

P210-P233-P240-P241-P242-P243-P260-P264-P270-P280-P303+P361+P353-P307+P311-P321-P370+P378-P403+P235-P405-P501
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

Cholic acid-d4 is intended for use as an internal standard for the quantification of cholic acid (Item No. 20250) by GC- or LC-MS. Cholic acid is a primary bile acid. It is formed from cholesterol via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. Cholic acid is conjugated to glycine or taurine by bile acid-CoA:amino acid N-acyltransferase (BAAT) to produce glycocholic acid (GCA; Item No. 20276) and taurocholic acid (TCA; Item No. 16215), respectively, in the liver, and is transformed into the secondary bile acid deoxycholic acid (DCA; Item No. 20756) by intestinal microbiota. It induces C. difficile colony formation in an agar dilution assay when used at a concentration of 0.1% w/v. Dietary administration of cholic acid (0.4% w/w) increases serum cholesterol levels, biliary phospholipid secretion, and fecal DCA levels in rats.
[Uses]

Cholic Acid-d4 is a labelled analog of Cholic acid (C432600) which is a choleretic produced by, and isolated from liver cells.
[Definition]

ChEBI:Cholic acid-2,2,4,4-d4 is a bile acid.
[storage]

Store at -20°C
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