| Identification | Back Directory | [Name]
5-HYDROXY ISATIN | [CAS]
116569-09-6 | [Synonyms]
5-HYDROXY ISATIN
Flumazenil Impurity 17
5-hydroxyindoline-2,3-dione
5-Hydroxy-1H-indole-2,3-dione
1H-Indole-2,3-dione, 5-hydroxy-
5-hydroxy-2,3-dihydro-1H-indole-2,3-dione
5-Hydroxy isatin 5-Hydroxy indole-2,3-dione | [Molecular Formula]
C8H5NO3 | [MDL Number]
MFCD11007925 | [MOL File]
116569-09-6.mol | [Molecular Weight]
163.13 |
| Hazard Information | Back Directory | [Biological Activity]
5-hydroxy Isatin is an inhibitor of monoamine oxidase A (MAO-A; IC50 = 8.4 μM).1 It is selective for MAO-A over MAO-B (IC50 = >100 μM). 5-hydroxy Isatin (50 μM) also inhibits atrial natriuretic peptide-induced activation of particulate guanylyl cyclase in rat brain and heart membranes.2 | [References]
1.Medvedev, A.E., Goodwin, B., Chow, A., et al.Inhibitory potency of some isatin analogues on human monoamine oxidase A and BBiochem. Pharmacol.44(3)590-592(1992)
2.Medvedev, A.E., Goodwin, B.L., Sandler, M., et al.Efficacy of isatin analogues as antagonists of rat brain and heart atrial natriuretic peptide receptors coupled to particulate guanylyl cyclaseBiochem. Pharmacol.57(8)913-915(1999)
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