| Identification | Back Directory | [Name]
11H-Dibenzo[b,e][1,4]dioxepin-11-one, 7-chloro-3,8-dihydroxy-4,9-dimethyl-1,6-bis(1-methyl-1-propenyl)- (9CI) | [CAS]
117032-54-9 | [Synonyms]
Emeguisin A
11H-Dibenzo[b,e][1,4]dioxepin-11-one, 7-chloro-3,8-dihydroxy-4,9-dimethyl-1,6-bis(1-methyl-1-propenyl)- (9CI) | [Molecular Formula]
C23H23ClO5 | [MOL File]
117032-54-9.mol | [Molecular Weight]
414.88 |
| Hazard Information | Back Directory | [Biological Activity]
Emeguisin A is a depsidone fungal metabolite originally isolated from E. unguis.1 It is active against the bacteria S. aureus and methicillin-resistant S. aureus (MRSA; MIC = 0.5 μg/ml for both), the fungus C. neoformans (MIC = 0.5 μg/ml), and the protozoan P. falciparum (IC50 = 2.2 μM).2 | [References]
1.Kawahara, N., Nozawa, K., Nakajima, S., et al.Isolation and structures of novel fungal depsidones, emeguisins A, B, and C, from Emericella unguisJ. Chem. Soc., Perkin Trans. 12611-2614(1988)
2.Klaiklay, S., Rukachaisirikul, V., Aungphao, W., et al.Depsidone and phthalide derivatives from the soil-derived fungus Aspergillus unguis PSU-RSPG199Tetrahedron Lett.57(39)4348-4351(2016)
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