| Identification | Back Directory | [Name]
Cholan-24-amide, N,3-dihydroxy-, (3α,5β)- | [CAS]
117094-40-3 | [Synonyms]
LCAHA
Cholan-24-amide, N,3-dihydroxy-, (3α,5β)- | [Molecular Formula]
C24H41NO3 | [MDL Number]
MFCD34469285 | [MOL File]
117094-40-3.mol | [Molecular Weight]
391.6 |
| Hazard Information | Back Directory | [Biological Activity]
LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a[1].
LCAHA inhibits HCT116wt and HCT116 p53-/- colon cancer cells viability with GI50s of 0.87±0.09 and 0.96±0.29μM, respectively, and the LD50s of 27.8±3.9 and 26.5±0.1μM, respectively[1]. | [References]
[1]. Katarzyna Magiera, et al. Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G 0/G1 Arrest by Inhibiting Deubiquitinase USP2a. Cell Chem Biol. 2017 Apr 20;24(4):458-470.e18. |
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