| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL; Ethanol: 1mg/mL | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
IM-93 is a dual inhibitor of ferroptosis and NETosis.1 It inhibits tert-butyl hydroperoxide- and erastin-induced ferroptosis in NIH3T3 cells (IC50s =1.8 and 1.9 nM, respectively), as well as decreases NETosis and lipid peroxidation induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human peripheral blood neutrophils when used at concentrations ranging from 1.6 to 25 μM. IM-93 also inhibits hydrogen peroxide-induced necrosis in HL-60 cells (IC50 = 0.45 μM), but has no effect on necroptosis induced by Fas ligand in combination with Z-VAD-FMK and cycloheximide in Jurkat cells or pyroptosis induced by S. aureus and P. aeruginosa in THP-1 cells when used at a concentration of 25 μM. | [storage]
Store at -20°C | [References]
1. Dodo, K., Kuboki, E., Shimizu, T., et al. Development of a water-soluble indolylmaleimide derivative IM-93 showing dual inhibition of ferroptosis and NETosis ACS Med. Chem. Lett. 10(9),1272-1278(2019). |
|
|