| Identification | Back Directory | [Name]
JAK2 Inhibitor III, SD-1029 | [CAS]
118372-34-2 | [Synonyms]
SD 1029
NSC371488
NSC-371488
NSC 371488
JAK2 Inhibitor III, SD-1029 | [Molecular Formula]
C25H32Br2Cl2N2O3 | [MDL Number]
MFCD31812651 | [MOL File]
118372-34-2.mol | [Molecular Weight]
639.247 |
| Hazard Information | Back Directory | [Description]
SD-1029 is a Janus kinase 2 (JAK2) inhibitor. It inhibits autophosphorylation of recombinant JAK2 when used at concentrations of 30 and 100 μM and decreases levels of phosphorylated JAK2, but not JAK1 or Src, in MDA-MB-468 and paclitaxel-resistant OVCAR8TR cells when used at a concentration of 10 μM. SD-1029 (10 μM) decreases levels of phosphorylated STAT3 in MDA-MB-468, MDA-BM-435, OVCAR8TR, and SKOV3TR cells and inhibits IL-6-induced nuclear translocation of STAT3 in BHK-21 and U2OS cells. It decreases the viability of and increases levels of cleaved caspase-3 in SNU-387, SNU-398, HepG2, and Huh7 hepatocellular carcinoma cells when used at a concentration of 10 μM. SD-1029 (100 and 1,000 nM) inhibits hepatitis A virus replication in GL37 cells. | [storage]
Store at -20°C |
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| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
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