| Identification | Back Directory | [Name]
2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine | [CAS]
118790-71-9 | [Synonyms]
IOS11212
IOS-11212
IOS 11212
Cerebrocrast
2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine
3,5-Pyridinedicarboxylic acid, 4-[2-(difluoromethoxy)phenyl]-1,4-dihydro-2,6-dimethyl-, 3,5-bis(2-propoxyethyl) ester | [Molecular Formula]
C26H35F2NO7 | [MDL Number]
MFCD00881282 | [MOL File]
118790-71-9.mol | [Molecular Weight]
511.56 |
| Hazard Information | Back Directory | [Description]
Cerebrocrast, also known as IOS-11212, is a calcium channel antagonist potentially for the treatment of cerebral vasospasm and cognition disorder. As Cerebrocrast decreased glucose levels in normal and streptozotocin (STZ)-induced diabetic rats, it also promoted glucose uptake by the brain, intensified insulin action and formation de novo of insulin receptors. Cerebrocrast did not alter current kinetics in either investigated channel, and the inhibition of calcium current was partly reversible or irreversible. As Cerebrocrast inhibited L- and T-type calcium channels, it can prevent vasoconstriction of kidney arterioles and aldosterone secretion that have significant roles in the development of hypertension and diabetic nephropathy. |
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