| Identification | Back Directory | [Name]
OXPRENOLOL | [CAS]
1189649-47-5 | [Synonyms]
OXPRENOLOL
Oxprenolol-d7 HCl
[2H7]-Oxprenolol Hydrochloride
2-PROPANOL,1-(2-ALLYLOXYPHENOXY)-3-(ISOPROPYLAMINO)-
1-(1,1,1,2,3,3,3-heptadeuteriopropan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol
1-(1,1,1,2,3,3,3-heptadeuteriopropan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol:hydrochloride | [Molecular Formula]
C15H23NO3 | [MDL Number]
MFCD34568051 | [MOL File]
1189649-47-5.mol | [Molecular Weight]
265.348 |
| Chemical Properties | Back Directory | [Melting point ]
97-98°C | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
Dichloromethane (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
pKa 9.5 (Uncertain) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Originator]
Trasicor,Ciba Geigy ,Italy,1970 | [Uses]
Oxprenolol is a free base of Oxprenolol Hydrochloride(O870500) which is a β-Adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic. | [Uses]
β-Adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic. | [Manufacturing Process]
75 grams of pyrocatechol monoallyl ether, 75 grams of epichlorohydrin, 75 grams of potassium carbonate and 400 ml of acetone are stirred and heated at the boil for 12 hours. The potassium carbonate is then filtered off. The solvent is distilled off in a water-jet vacuum. The residual oil is dissolved in ether and agitated with 2 N sodium hydroxide solution. The ether is separated, dried and distilled off. The residue is distilled in a water-jet vacuum. 3-(ortho-allyloxy-phenoxy)-1,2-epoxypropane passes over at 145° to 157°C under 11 mm Hg pressure. A solution of 15 grams of 3-(ortho-allyloxyphenoxy)-1,2-epoxypropane and 15 grams of isopropylamine in 20 ml of ethanol is refluxed for 4 hours. The excess amine and the alcohol are then distilled off under vacuum, to leave 1-isopropylamino-2-hydroxy-3-(orthoallyloxy-phenoxy)-propane which melts at 75° to 80°C after recrystallization from hexane.
| [Therapeutic Function]
Antiarrhythmic |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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