| Identification | Back Directory | [Name]
CZC-54252 | [CAS]
1191911-27-9 | [Synonyms]
CS-1730
CZC-54252
CZC-54252, >98%
CZC 54252;CZC54252
CZC 54252 hydrochloride
N-(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)pyrimidin-4-ylamino)phenyl)methanesulfonamide
N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide
Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-
N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride | [Molecular Formula]
C22H25ClN6O4S | [MDL Number]
MFCD26401527 | [MOL File]
1191911-27-9.mol | [Molecular Weight]
504.99 |
| Chemical Properties | Back Directory | [Boiling point ]
718.1±70.0 °C(Predicted) | [density ]
1.452±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMF: 20 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 10 mg/mL | [form ]
Powder | [pka]
8.50±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CZC 54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2). LRRK2 mutations are associated with familial Parkinson''s disease and a potential therapeutic target. | [Definition]
ChEBI: CZC-25146 is a member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(morpholin-4-yl)phenyl and 2-(methanesulfonylamino)phenyl substituents. It is an inhibitor of the Parkinson's disease kinase LRRK2. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is an aminopyrimidine, a member of morpholines, an aromatic ether, an organochlorine compound, a sulfonamide and a secondary amino compound. | [storage]
Store at -20°C |
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D&C Chemicals
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BOC Sciences
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www.bocsci.com |
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