| Identification | Back Directory | [Name]
4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- | [CAS]
1197300-24-5 | [Synonyms]
TGR5
CCDC
CS-1017
MDK00245
TGR5 Receptor Agonist
CCDC(TGR5-Receptor-Agonist)
TGR5 Receptor Agonist, >=98%
BENZYL (4-CHLORO-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETATE
3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-4-IsoxazolecarboxaMide
3-(2-CHLOROPHENYL)-N-(4-CHLOROPHENYL)-N,5-DIMETHYLISOXAZOLE-4-CARBOXAMIDE
4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-
3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide
3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-4-isoxazolecarboxamide TGR5
TGR5 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- | [EINECS(EC#)]
200-256-5 | [Molecular Formula]
C18H14Cl2N2O2 | [MDL Number]
MFCD17169972 | [MOL File]
1197300-24-5.mol | [Molecular Weight]
361.22 |
| Chemical Properties | Back Directory | [Boiling point ]
541.8±50.0 °C(Predicted) | [density ]
1.346±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 30 mg/ml | [form ]
A crystalline solid | [pka]
-0.52±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
TGR5 receptor agonist is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50s = 31.6-158.5 nM in cell-based assays). It stimulates cAMP formation in HEK293 cells expressing TGR5 (EC50 = 2.3 pM). TGR5 receptor agonist (1 mg/kg) increases glucagon-like peptide 1 (GLP-1) secretion and decreases glucose levels in the hepatic portal vein in dogs when administered in combination with glucose. It also inhibits the cytochrome P450 (CYP) isozymes CYP2C19 and CYP3A4 (IC50s = 316.2 and 1,259 nM, respectively). |
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