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119959-65-8

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119959-65-8 Structure

119959-65-8 Structure
IdentificationBack Directory
[Name]

2-[(1-OXO-5Z,8Z,11Z,14Z-EICOSATETRAENYL)AMINO]-ETHANE SULFONIC ACID
[CAS]

119959-65-8
[Synonyms]

N-ARACHIDONOYL TAURINE
N-Arachidonoyl Taurine Exclusive
2-[(1-OXO-5Z,8Z,11Z,14Z-EICOSATETRAENYL)AMINO]-ETHANE SULFONIC ACID
Ethanesulfonic acid, 2-[[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]amino]-
[Molecular Formula]

C22H37NO4S
[MDL Number]

MFCD08062154
[MOL File]

119959-65-8.mol
[Molecular Weight]

411.6
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 10 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 1.5 mg/ml
[form ]

A crystalline solid
Hazard InformationBack Directory
[Description]

N-Arachidonoyl taurine is an arachidonoyl amino acid. It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages. N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 (EC50s = 28 and 21 μM, respectively). It increases calcium flux in HIT-T15 pancreatic β-cells and INS-1 rat islet cells when used at a concentration of 10 μM and increases insulin secretion from 832/13 INS-1 pancreatic β-cells. The levels of N-arachidonoyl taurine are changed in mouse brain following administration of Δ9-tetrahydrocannabinol (Δ9-THC).
[Uses]

N-Arachidonoyltaurine is a polyunsaturated lipid that inhibits the Cav3.3 current in T-type calcium channels.
[Definition]

ChEBI: A fatty acid-taurine conjugate derived from arachidonic acid.
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