| Chemical Properties | Back Directory | [Boiling point ]
415.9±55.0 °C(Predicted) | [density ]
1.504±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 250 mg/mL (1031.91 mM; Need ultrasonic) | [form ]
Solid | [pka]
8.88±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM)[1].
BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics[1]. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold)[1]. | [storage]
4°C, protect from light | [References]
[1]. Anja Probst Larsen, et al. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol Pharmacol. 2017 Jun;91(6):576-585. |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|