| Identification | Back Directory | [Name]
diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate | [CAS]
120533-76-8 | [Synonyms]
BML-278
DI ETHYL 1 BENZYL 4 PHENYL 4H PYRIDINE 3-5 DICARBOXYLATE
Diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-phenyl-1-(phenylmethyl)-, 3,5-diethyl ester | [Molecular Formula]
C24H25NO4 | [MOL File]
120533-76-8.mol | [Molecular Weight]
391.46 |
| Chemical Properties | Back Directory | [Melting point ]
139-141 °C(Solv: cyclohexane (110-82-7); benzene (71-43-2)) | [Boiling point ]
525.5±50.0 °C(Predicted) | [density ]
1.183±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in DMSO (up to 5 mg/ml). | [form ]
solid | [pka]
2.05±0.70(Predicted) | [color ]
Off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
BML-278 (120533-76-8) is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permeable. | [Uses]
Diethyl 1-Benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is a cell-permeable and potent SIRT activator that induces cell cycle arrest. SIRT modulators have therapeutic potential the treatment of cancer, cardiovascular, metabolic, inflammatory, and neurodegenerative diseases. | [Definition]
ChEBI: 4-phenyl-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid diethyl ester is a dihydropyridine. | [storage]
Store at -20°C | [References]
1) Mai et al. (2009), Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors; J. Med.Chem.,52 5496 |
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