| Identification | Back Directory | [Name]
Bozepinib | [CAS]
1207993-83-6 | [Synonyms]
Bozepinib
4,1-Benzoxazepine, 3-(2,6-dichloro-9H-purin-9-yl)-1,2,3,5-tetrahydro-1-[(4-nitrophenyl)sulfonyl]- | [Molecular Formula]
C20H14Cl2N6O5S | [MOL File]
1207993-83-6.mol | [Molecular Weight]
521.33 |
| Hazard Information | Back Directory | [Enzyme inhibitor]
This potent antitumor agent (FW = 521.33 g/mol), sysyematically known as (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1- benzoxazepin-3-yl]-9H-purine, induces apoptosis in breast and colon cancer cells via inhibition (IC50 = 0.3–2 μM) of the the double-stranded RNAdependent protein kinase, PKR, but not p53. Moreover, interferon enhances cytotoxicity of bozepinib in colon and breast cancer cells by increasing apoptotic cell death. |
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