| Identification | Back Directory | [Name]
2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]-pentanamide dihydrochloride | [CAS]
1214672-15-7 | [Synonyms]
LM11A-31 dihydrochloride
LM11A-31 dihydrochloride >=95% (HPLC)
2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]-pentanamide dihydrochloride
(Rac)LM11A31 dihydrochloride,(Rac) LM11A 31 dihydrochloride,(Rac)-LM-11A-31 dihydrochloride | [Molecular Formula]
C12H26ClN3O2 | [MDL Number]
MFCD11505486 | [MOL File]
1214672-15-7.mol | [Molecular Weight]
279.81 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Water: ≥ 200 mg/mL (632.37 mM); Ethanol: 100 mg/mL (316.19 mM) | [form ]
oil | [color ]
colorless to yellow |
| Hazard Information | Back Directory | [Uses]
LM11A-31 dihydrochloride has been used to study the effect of p75 neurotrophin receptor (p75 NTR) blockade, by non-peptide LM11A-31 ligand, on PC12?cell viability. | [Biochem/physiol Actions]
LM11A-31 is a non-peptide ligand of the p75 neurotrophin receptor (p75NTR). LM11A-31 blocks pro-NGF induced cell death in neuronal cultures, and protects neuronal cells from the the cytotoxic effects of cisplatin or methotrexate. Oral administration of LM11A-31 promotes the survival of oligodendrocytes and myelinated axons in a mouse spinal cord injury model and improves function in both weight-bearing and non-weight bearing tests. | [storage]
Store at -20°C |
|
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Sigma-Aldrich
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DC Chemicals
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Energy Chemical
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