| Identification | Back Directory | [Name]
4-oxo-27-TBDMS Withaferin A | [CAS]
1214886-31-3 | [Synonyms]
4-oxo-27-TBDMS Withaferin A
Ergosta-2,24-dien-26-oic acid, 27-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,6-epoxy-22-hydroxy-1,4-dioxo-, δ-lactone, (5β,6β,22R)- | [Molecular Formula]
C34H50O6Si | [MOL File]
1214886-31-3.mol | [Molecular Weight]
582.85 |
| Hazard Information | Back Directory | [Description]
4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells. | [References]
1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells J. Med. Chem. 62(9),4571-4585(2019). |
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