| Identification | Back Directory | [Name]
MMPIP (hydrochloride) | [CAS]
1215566-78-1 | [Synonyms]
242084
CS-1472
CS-2104
SB-242084 HCl
MMPIP hydrochloride (479077-02-6 Free base)
6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide
MMPIP hydrochloride,MMPIP,system,nervous,neuropathic,behavior,pain,inhibit,central,glutamate,cognitive,allosteric,Metabotropic glutamate receptors,Inhibitor,metabotropic,mGluR,mGluR7 | [Molecular Formula]
C19H16ClN3O3 | [MOL File]
1215566-78-1.mol | [Molecular Weight]
369.802 |
| Hazard Information | Back Directory | [Description]
MMPIP is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization (IC50 = 26 nM). It does not affect other mGlu receptors. The modulation of mGluR7 by MMPIP is context dependent, in that it is not observed in all known mGluR7 signaling pathways. MMPIP has been used to investigate the role of mGluR7 in cocaine-mediated reward signaling, attention and impulse control, and cognitive behavior in mice and rats. MMPIP also reversibly inhibits constitutive activity of mGluR7 in sympathetic neurons from the rat superior cervical ganglion. | [Uses]
MMPIP Hydrochloride is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization. | [Definition]
ChEBI: 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride is an organic molecular entity, an indole alkaloid and a pyridine. It has a role as a receptor modulator. |
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| Company Name: |
Cckinase, Inc.
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| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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