| Identification | Back Directory | [Name]
(2S,3S)-N-((S)-1-(4-(5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)-3-hydroxypyrrolidine-2-carboxamide | [CAS]
1218816-71-7 | [Synonyms]
SK1-IN-1
SK1 inhibitor 1
(2S,3S)-N-((S)-1-(4-(5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)-3-hydroxypyrrolidine-2-carboxamide
2-Pyrrolidinecarboxamide, N-[(1S)-1-[4-[5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-3-hydroxy-, (2S,3S)- | [Molecular Formula]
C22H30N4O3 | [MDL Number]
MFCD31382196 | [MOL File]
1218816-71-7.mol | [Molecular Weight]
398.5 |
| Hazard Information | Back Directory | [Biological Activity]
SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with IC50 of 58 nM. | [in vivo]
SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. It is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation demonstrates . | [target]
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