ChemicalBook--->CAS DataBase List--->1221413-57-5

1221413-57-5

1221413-57-5 Structure

1221413-57-5 Structure
IdentificationBack Directory
[Name]

CAY10638
[CAS]

1221413-57-5
[Synonyms]

CAY10638
CAY10638 Exclusive
2,4-Thiazolidinedione, 5-[[4-[2-(2-thienyl)ethoxy]phenyl]methylene]-
[Molecular Formula]

C16H13NO3S2
[MDL Number]

MFCD18382124
[MOL File]

1221413-57-5.mol
[Molecular Weight]

331.41
Chemical PropertiesBack Directory
[solubility ]

DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 25 mg/ml
[form ]

A crystalline solid
Hazard InformationBack Directory
[Description]

Prostaglandins have a short life in vivo because NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity.1 Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity.2,3 CAY10638 is a TZD derivative that inhibits 15-PGDH activity with an IC50 value of 31 nM.3
[Definition]

ChEBI: CAY10638 is an aromatic ether.
[References]

1. Hansen, H.S. 15-Hydroxyprostaglandin dehydrogenase. A review Prostaglandins 12(4),647-679(1976).
2. Owens, D.R. Thiazolidinediones. An pharmacological overview Clin. Drug Investig. 22(8),485-505(2002).
3. Wu, Y., Tai, H.H., and Cho, H. Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors Bioorg. Med. Chem. 18,1428-1433(2010).
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