| Identification | Back Directory | [Name]
Sodium aurothiomalate | [CAS]
12244-57-4 | [Synonyms]
autm
kidon
D00992
tauredon
myocrisin
miochrysin
Miocrisina
Myocrisine
myochrysine
chrysothios
taure(o)don
GOLDTHIOMALATE
Myochrysine (tn)
sodiumaurithiomalate
SODIUM AUROTHIOMALATE
aurothiomaleatesodium
disodiumaurothiomalate
Gold sodium thiomaleate
SODIUM AUROTHIOMALATE(I)
Gold sodium thiomalate (usp)
Sodium aurothiomalate (jp15)
disodium 2-(auriothio)succinate
mercapto-succinicacigoldsodiumsalt
(mercaptobutanedioato(1-))golddisodiumsalt
((1,2-dicarboxyethyl)thio)-goldisodiumsalt
Sodiumaurothiomalate(I),99.9%(metalsbasis)
((1,2-dicarboxyethyl)thio)golddisodiumsalt
(dihydrogenmercaptosuccinato)golddisodiumsalt
mercapto-butanedioicacimonogold(1+)sodiumsalt
(1,2-dicarboxyethylthio)gold disodium salt hydrate
Butanedioic acid, mercapto-, monogold(1+) sodium salt
(1,2-Dicarboxyethylthio)gold hydrate disodium salt, Gold sodium thiomalate hydrate
NSCLC,inhibit,NF-kB,PKC,A427,Aurothiomalate,Erk,SCLC,Inhibitor,H460,H1703,Aurothiomalate sodium,thioredoxin,Mek,A549,H1437,reductase,anti-rheumatoid,H510,LAC,H187,TrxR,Protein kinase C,LACs,H2170,TNFa | [EINECS(EC#)]
235-479-7 | [Molecular Formula]
C4H3AuNa2O4S | [MDL Number]
MFCD00064304 | [MOL File]
12244-57-4.mol | [Molecular Weight]
390.08 |
| Chemical Properties | Back Directory | [Definition]
White to yellowish-white powder; odorless; metallic taste. Affected by light. Very soluble in water; practically insoluble in alcohol and ether; aqueous solutions are colorless to pale yellow; pH
(5% solution) 5.8–6.5. | [storage temp. ]
4°C, away from moisture | [form ]
Solid | [color ]
Off-white to light yellow | [Water Solubility ]
Very soluble in water. Practically insoluble in alcohol, ether | [Merck ]
14,4518 |
| Hazard Information | Back Directory | [Uses]
Medicine (antirheumatic). | [Brand name]
Myochrysine (Merck). | [Physical properties]
White to yellowish white powder; odorless; metallic taste; highly soluble in water; practically insoluble in ethanol and ether. | [Production Methods]
Gold(I) thiomalate is prepared by reacting sodium thiomalate with gold(I) halide. It is stored in the dark and otherwise protected from light. | [Pharmaceutical Applications]
Sodium aurothiomalate is a commonly used gold-based DMARD and is indicated for active progressive
RA. It is administered by deep intramuscular injection. Administration is started with a test dose of 10mg
followed by weekly intervals of 50 mg doses. An improvement is expected to be seen once 300–500 mg
is administered. Treatment should be discontinued if there is no improvement after administering 1 g or
2months. Intervals of administration should be gradually increased to 4weeks in patients in whom an effect can be seen. If any blood disorders or other side effects such as GI bleedings or proteinuria are observed,
sodium aurothiomalate should be discontinued. | [Clinical Use]
Active progressive rheumatoid arthritis in adults | [Synthesis]
Synthesis: a solution of thiomalic acid and 3
equivalents of sodium hydroxide are mixed with
an aqueous suspension of gold(I) iodide. The
product, a mixture of the mono- and disodium
salts, is precipitated by the addition of ethanol.
 | [Drug interactions]
Potentially hazardous interactions with other drugs
ACE-inhibitors: flushing and hypotension reported
in combination.
Penicillamine: increased risk of toxicity - avoid. | [Metabolism]
Mainly excreted in the urine with smaller amounts in the
faeces. |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
20/21/22-43 | [Safety Statements ]
36 | [WGK Germany ]
3
| [RTECS ]
MD5435000
| [Safety Profile]
Poison by
subcutaneous and intramuscular routes.
Moderately toxic bj intravenous ' route.
Human systemic effects: aggression,
agranulocytosis, aplastic anemia, cell count
changes, changes in circulation, cholestatic
jaunhce, dermatitis, encephalitis,
fasciculations, flaccid paralysis without
anesthesia, hemorrhage, hepatitis
(hepatocellular necrosis), increased body
temperature, interstitial fibrosis, muscle
weakness, proteinuria, recording from
peripheral motor nerve, depressed renal
function tests, somnolence, structural
changes in nerve sheath, thrombocytopenia,
uncharacterized allergc reaction, changes in
blood, teeth, and supporting structures.
Experimental teratogenic and reproductive
effects. When heated to decomposition it emits very toxic Na2O and SOx. | [Hazardous Substances Data]
12244-57-4(Hazardous Substances Data) |
|
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SG Pharma Pvt Ltd
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Energy Chemical
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Sigma-Aldrich
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https://www.sigmaaldrich.cn |
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