| Identification | Back Directory | [Name]
AG 99 | [CAS]
122520-85-8 | [Synonyms]
AG 99
(E)-AG 99
TYRPHOSTIN 46
TYRPHOSTIN A46
TYRPHOSTIN B40
AG 99 USP/EP/BP
TYRPHOSTIN AG 99
(E)-Tyrphostin 46
TYRPHOSTIN A46 99%
(E)-Tyrphostin AG 99
3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE
ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMIDE
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide
2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)propenamide
(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-2-PROPENAMIDE
2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-
2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) | [Molecular Formula]
C10H8N2O3 | [MDL Number]
MFCD00133901 | [MOL File]
122520-85-8.mol | [Molecular Weight]
204.18 |
| Chemical Properties | Back Directory | [Melting point ]
247 °C | [Boiling point ]
544.4±50.0 °C(Predicted) | [density ]
1.482±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Soluble in DMSO | [form ]
Brown solid. | [pka]
8.81±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Tyrphostin AG 99 is a potent, cell-permeable and reversible inhibitor of EGFR and EGF-dependent cell proliferation. | [Biological Activity]
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro . | [References]
[1]. gazit a, osherov n, gilon c, et al. tyrphostins. 6. dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of egf receptor tyrosine kinase in vitro. j med chem, 1996, 39(25): 4905-4911.
[2]. yamamoto n, mammadova g, song rx, et al. tyrosine phosphorylation of p145met mediated by egfr and src is required for serum-independent survival of human bladder carcinoma cells. j cell sci, 2006, 119(pt 22): 4623-4633. |
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| Company Name: |
TCI Europe
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| Tel: |
320-37350700 |
| Website: |
https://www.tcichemicals.com/de/de/index.html |
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