| Identification | Back Directory | [Name]
TYRPHOSTIN A51 | [CAS]
122520-90-5 | [Synonyms]
AG 183
TYRPHOSTIN 51
TYRPHOSTIN A51
TYRPHOSTIN AG 183
TYRPHOSTIN A51 99+%
TYRPHOSTIN A51 USP/EP/BP
2-AMINO-1,1,3-TRICYANO-4-[3',4',5'-TRIHYDROXYPHENYL]BUTADIENE
2-AMINO-4-(3',4',5'-TRIHYDROXYPHENYL)-1,1,3-TRICYANOBUTA-1,3-DIENE
3-AMINO-2,4-DICYANO-5-(3',4',5'-TRIHYDROXYPHENYL)PENTA-2,4-DIENONITRILE
1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (Z)-
1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (3Z)- | [Molecular Formula]
C13H8N4O3 | [MDL Number]
MFCD00133903 | [MOL File]
122520-90-5.mol | [Molecular Weight]
268.23 |
| Chemical Properties | Back Directory | [Melting point ]
275 °C | [Boiling point ]
788.2±60.0 °C(Predicted) | [density ]
1.591±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
≤20mg/ml in DMSO;20mg/ml in dimethyl formamide | [form ]
Orange solid. | [pka]
8.46±0.15(Predicted) |
| Hazard Information | Back Directory | [Description]
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 0.8 μM in the human epidermoid carcinoma cell line A431. | [Uses]
Tyrphostin 51 is a potent inhibitor of EGFRK activity showing mixed competitive inhibition with ATP and substrate1-3.. | [Definition]
ChEBI: 2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile is a benzenetriol. | [References]
[1] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[2] hubbard s r, till j h. protein tyrosine kinase structure and function[j]. annual review of biochemistry, 2000, 69(1): 373-398. |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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