| Identification | Back Directory | [Name]
MYCALOLIDE B | [CAS]
122752-21-0 | [Synonyms]
MYCALOLIDE B
Mycalolide B, Mycale sp.
MYCALOLIDE B, MYCALE SPECIES
4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C
Propanoic acid, 2,3-dimethoxy-, (1R,2S,3R,4R,5E)-3-(acetyloxy)-6-(formylmethylamino)-1-[(3S,4S)-5-[(10S,11R,13E,16S,20S,21R,22S,24E)-16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-2(31),4,6(30),8,13,24,26(29),28-octaen... | [Molecular Formula]
C52H74N4O17 | [MDL Number]
MFCD00272618 | [MOL File]
122752-21-0.mol | [Molecular Weight]
1027.16 |
| Chemical Properties | Back Directory | [alpha ]
-53.4℃ (D) (c=1.3 CHCl3) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 20 mg/ml) | [form ]
Clear to white solid | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
Mycalolide B (122752-21-0) is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM).1?It selectively and completely depolymerizes F-actin to G-actin?via?a novel mechanism different from that of the cytochalasin D.2?It is a novel and specific inhibitor of actomyosin ATPase.3 | [References]
1) Saito et al. (1994), Mycalolide B, a novel actin depolymerizing agent; J. Biol. Chem., 269 29710
2) Sugidachi et al. (1998), Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D; Thromb. Haemost., 79 614
3) Hori et al. (1993), Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge; FEBS Lett., 322 151 |
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| Company Name: |
Boppard-China
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| Tel: |
021-62884751 |
| Website: |
www.boppard.cn |
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