ChemicalBook--->CAS DataBase List--->1235034-55-5

1235034-55-5

1235034-55-5 Structure

1235034-55-5 Structure
IdentificationBack Directory
[Name]

A-1155463
[CAS]

1235034-55-5
[Synonyms]

A-1155463
A-1155463; A 1155463; A1155463.
2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-(4-(3-(dimethylamino)prop-1-ynyl)-2-fluorophenoxy)propyl)thiazole-4-carboxylic acid
4-Thiazolecarboxylic acid, 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-
2-[8-(1,3-Benzothiazol-2-ylcarbamoyl)-3,4-dihydro-2(1H)-isoquinolinyl]-5-(3-{4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy}propyl)-1,3-thiazole-4-carboxylic acid
[Molecular Formula]

C35H32FN5O4S2
[MDL Number]

MFCD29924714
[MOL File]

1235034-55-5.mol
[Molecular Weight]

669.79
Chemical PropertiesBack Directory
[density ]

1.45±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

≥67 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
[form ]

solid
[pka]

1.11±0.36(Predicted)
[color ]

Off-white to yellow
Hazard InformationBack Directory
[Uses]

A-1155463 Hydrochloride, is a potent and selective BCL-XL inhibitor with in vivo activity. A-1155463 is a proteolytically stable, cell-permeable and high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of <0.01nM (<10 pM), highly selective against closely related proteins of BCL-2 (Ki = 74nM, >7000-fold selectivity), BCL-W (Ki = 8 nM, >800-fold selectivity), and MCL-1 (Ki >444nM, >40000-fold selectivity). A-1155463, together with A-1331852 , represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity. In living cells, A-1155463, as anticipated, experts an effort to disrupt the tight-binding BCL-XL-BIM, but not BCL-2–BIM, complexes, killi
[Biological Activity]

ki=19 nma-1155463 is a potent and selective bcl-xl inhibitor.bcl-2 plays a key role in the survival of lymphoid malignancies, while bcl-xl overexpression has been associated with drug resistance and disease progression of various solid tumors and hematological malignancies.
[in vitro]

a-1155463 was identified via nuclear magnetic resonance fragment screening and structure-based design to be a highly potent and selective bcl-xl inhibitor. a-1155463 was found to be substantially more potent against bcl-xl-dependent cell lines relative to the previously reported inhibitor, wehi-539 [1].
[in vivo]

animal study showed that following a single ip dose of a-1155463 at 5 mg/kg in nontumor bearing scid-beige mice, platelet counts dramatically decreased at 6 h postdose and then rebounded to normal levels within 72 h. such platelet depletion and recovery kinetics were similar to those of the dual inhibitor navitoclax. moreover, in order to give additional evidence that a-1155463 was conferring on-target in-vivo activity, a-1155463 was then administered to scidbeige mice that had been inoculated with bcl-xl-dependent h146 tumor cells. results showed that the daily ip dosing of a-1155463 at 5 mg/kg for 14 days caused a statistically significant inhibition of tumor growth, which was alleviated upon cessation of dosing [1].
[target]

TargetValue
BCL-XL
(Cell-free assay)
<0.01 nM(Ki)
[storage]

Store at -20°C
[References]

[1] tao zf et al. discovery of a potent and selective bcl-xl inhibitor with in vivo activity. acs med chem lett. 2014 aug 26;5(10):1088-93.
Spectrum DetailBack Directory
[Spectrum Detail]

A-1155463(1235034-55-5)MS
1235034-55-5 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226 , 13588875226
Website: www.hzclap.com/en
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471 , +1-2135480471
Website: https://www.sarms4muscle.com
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054 , 13417589054
Website: www.chemicalbook.com/ShowSupplierProductsList1962465/0.htm
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525 , +8618327326525
Website: topule.com/
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: Wuhan Fortuna Chemical Co.,Ltd
Tel: +8618007136271 , +8618007136271
Website: https://www.chemicalbook.com/manufacturer/Wuhan%20Fortuna%20chemical/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Shanghai Luofa Biochemical Technology Co., Ltd.  Gold
Tel: 021-51111890 15317326293
Website: www.molnova.cn/
Company Name: Shanghai YuanQi Biotechnology Co., Ltd.  Gold
Tel: +86-2332782371 +86-18120098618
Website: https://www.chemicalbook.com/ShowSupplierProductsList16784/0.htm
Company Name: SuZhou GoodChemTech Co., Ltd  Gold
Tel: 18136139868
Website:
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Website: www.boylechem.com
Company Name: Chembest Research Laboratories Limited  
Tel: +86-21-20908456
Website: http://www.BioChemBest.com
Company Name: Nanjing Chemlin Chemical Co., Ltd  
Tel: 025-83697070
Website: www.echemlin.cn
Company Name: Haoyuan Chemexpress Co., Ltd.  
Tel: 021-58950125
Website: http://www.chemexpress.com.cn
Tags:1235034-55-5 Related Product Information