| Identification | Back Directory | [Name]
2-phenylsulfanylethyl methyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-d icarboxylate | [CAS]
123875-01-4 | [Synonyms]
2-phenylsulfanylethyl methyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-d icarboxylate
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, 3-methyl 5-[2-(phenylthio)ethyl] ester | [Molecular Formula]
C19H23NO4S | [MOL File]
123875-01-4.mol | [Molecular Weight]
361.46 |
| Hazard Information | Back Directory | [Uses]
PCA 4248 is a competitive inhibitor of PAF at the PAF-R level. | [Definition]
ChEBI: 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-[2-(phenylthio)ethyl] ester is a dihydropyridine. | [Biological Activity]
A specific PAF antagonist, more potent than the ginkolide BN-52021. Inhibits rabbit platelet aggregation with an IC 50 value of 1.05 μ M and has no significant activity on Ca 2+ channels. Active in vivo , antagonising PAF-induced systemic hypotension and protein-plasma extravasation in rats. | [storage]
Desiccate at -20°C |
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