| Identification | Back Directory | [Name]
A971432 | [CAS]
1240308-45-5 | [Synonyms]
A971432
A971432,A 971432
A-971432 >=95% (HPLC)
1-(4-((3,4-dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic acid
1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid | [EINECS(EC#)]
827-461-8 | [Molecular Formula]
C18H17Cl2NO3 | [MDL Number]
MFCD30182357 | [MOL File]
1240308-45-5.mol | [Molecular Weight]
366.24 |
| Hazard Information | Back Directory | [Uses]
A 971432 is used in the preparation of benzylazetidinecarboxylate derivatives as agonists and antagonists of the S1P5 receptor. | [Biochem/physiol Actions]
A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50?= 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay) without affect the activity of 129 protein kinases (IC50?>10 μM). A-971432 is shown to enhance blood-brain barrier integrity and reverse lipid accumulation and age-related cognitive decline in mice in vivo with good pharmacokinetics (t1/2??= 5.7 h; Cmax?= 2,500 ng/ml; AUC = 35,000 ng.h/ml at 10 mg/kg, p.o. in CD1 mice). Likewise, oral gavage showed good plasma exposure and no sign of lymphopenia in rats (10, 30, and 100 mg/kg. | [storage]
Store at RT |
|
| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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